Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.53 |
| ▸ | PPARA | Q07869 | 3/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATP4A | P20648 | 1/20 | 0.43 |
| ▸ | ATP4B | P51164 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9005921 | 0.90 | TP53 (0.52) | PPARGPPARATP53LMNAMAPT | |
| SCHEMBL9261010 | 0.87 | PPARG (0.51) | PPARGPPARAALOX5TP53LMNA | |
| SCHEMBL9261216 | 0.87 | ALDH1A1 (0.55) | PPARGPPARATP53LMNAMAPT | |
| SCHEMBL9263830 | 0.86 | PPARA (0.51) | PPARGPPARAALOX5TP53MAPT | |
| SCHEMBL9261712 | 0.84 | TP53 (0.53) | PPARGPPARAALOX5PSEN1TP53 | |
| SCHEMBL9089772 | 0.81 | PPARG (0.53) | PPARGPPARAALOX5MAOBPPARD | |
| SCHEMBL9005898 | 0.79 | PPARA (0.57) | PPARGPPARATP53LMNAMAPT | |
| SCHEMBL9266531 | 0.79 | TP53 (0.51) | PPARGPPARAALOX5PSEN1TP53 | |
| SCHEMBL9594793 | 0.79 | PPARA (0.55) | PPARGPPARAALOX5TP53LMNA | |
| SCHEMBL9264234 | 0.78 | ALOX5 (0.50) | PPARGPPARAALOX5PSEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459154-A | Enzyme inhibitors as antiinflammatory agents and treatment of atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-10-17 | — | — | US | claimed |
| US-5459154-A | Enzyme inhibitors as antiinflammatory agents and treatment of atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-10-17 | — | — | US | disclosed |