Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28239625 | 0.83 | HRH3 (0.58) | HRH3KMT2AHRH4TAAR1SMN1; SMN2 | |
| SCHEMBL10735316 | 0.72 | DHFR (0.46) | HRH3HRH4TAAR1 | |
| SCHEMBL10653116 | 0.68 | PLA2G7 (0.48) | PDE3BPDE3A | |
| SCHEMBL8652815 | 0.68 | HRH3 (0.57) | HRH3NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL9948003 | 0.68 | HRH3 (0.62) | HRH3KMT2AHRH4MAPT | |
| SCHEMBL21803711 | 0.67 | HRH3 (0.43) | HRH3PDE3BPDE3AKMT2ATAAR1 | |
| SCHEMBL9259240 | 0.67 | HRH3 (0.40) | HRH3PDE3BPDE3AHTR1D | |
| SCHEMBL8320778 | 0.66 | RARB (0.42) | HRH3NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL6605700 | 0.66 | MEN1 (0.47) | PDE3BPDE3AKMT2ACYP3A4MAPT | |
| SCHEMBL25435625 | 0.65 | ALDH1A1 (0.39) | HRH3NPC1RAB9AKMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6009625-A | — | — | None | — | — | JP | disclosed |
| US-5430149-A | 5-[(4-bromophenyl)methyl]4-pyrimidinones | SYNTHELABO (FR) | 1995-07-04 | — | — | US | disclosed |
| US-5430149-A | 5-[(4-bromophenyl)methyl]4-pyrimidinones | SYNTHELABO (FR) | 1995-07-04 | — | — | US | disclosed |
| US-5312920-A | Process for preparing 4-pyrimidinones | SYNTHELABO (FR) | 1994-05-17 | — | — | US | disclosed |
| JP-H069625-A | NEW PRODUCTION OF 4-PYRIMIDINONES | SYNTHELABO SA | 1994-01-18 | — | — | JP | disclosed |