Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | DBH | P09172 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL308403 | 0.76 | ALDH1A1 (0.47) | ALDH1A1MAPTPOLBGFERCACNA1B | |
| SCHEMBL27752664 | 0.70 | ALDH1A1 (0.65) | ALDH1A1ACHEHSD17B10APPLMNA | |
| SCHEMBL28818 | 0.70 | — | — | |
| SCHEMBL27909482 | 0.69 | ALDH1A1 (0.72) | ALDH1A1ACHEHSD17B10APPLMNA | |
| SCHEMBL22567 | 0.69 | ALDH1A1 (0.72) | ALDH1A1ACHEHSD17B10APPLMNA | |
| Nitric Acid SCHEMBL27633027 | 0.68 | CES1 (0.64) | ALDH1A1ACHEHSD17B10LMNACES1 | |
| SCHEMBL28198 | 0.68 | CA1 (0.67) | ALDH1A1MAPTPOLBACHEHSD17B10 | |
| SCHEMBL6423919 | 0.68 | CA1 (0.67) | ALDH1A1MAPTPOLBACHEHSD17B10 | |
| Water SCHEMBL28241270 | 0.67 | ALDH1A1 (0.68) | ALDH1A1ACHEHSD17B10APPLMNA | |
| Water SCHEMBL27300423 | 0.67 | ALDH1A1 (0.68) | ALDH1A1ACHEHSD17B10APPLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2540320-A1 | LEPTOMYCIN DERIVATIVES | SANOFI (FR) | 2013-01-02 | — | — | EP | disclosed |
| EP-2032172-B1 | LEPTOMYCIN DERIVATIVES | SANOFI SA (FR) | 2012-06-06 | — | — | EP | disclosed |
| US-20110002947-A1 | LEPTOMYCIN DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-01-06 | — | — | US | disclosed |
| US-7816543-B2 | Leptomycin derivatives | SANOFI-AVENTIS (FR) | 2010-10-19 | — | — | US | disclosed |
| US-20090182038-A1 | Leptomycin Derivatives | SANOFI-AVENTIS (FR) | 2009-07-16 | — | — | US | disclosed |
| EP-2032172-A2 | LEPTOMYCIN DERIVATIVES | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | disclosed |
| US-7456309-B2 | Reusable universal polymer support for repetitive oligonucleotide synthesis | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2008-11-25 | — | — | US | disclosed |
| WO-2007144709-A2 | LEPTOMYCIN DERIVATIVES | SANOFI-AVENTIS (FR) | 2007-12-21 | — | — | WO | disclosed |
| EP-1864682-A1 | Leptomycin derivatives | Sanofi-Aventis (FR) | 2007-12-12 | — | — | EP | disclosed |
| US-7235650-B2 | Derivatized oligonucleotides having improved uptake and other properties | ISIS PHARMACEUTICALS, INC. (US) | 2007-06-26 | — | — | US | disclosed |
| EP-0804456-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS, INC. (US) | 1997-11-05 | — | — | EP | disclosed |
| US-5578718-A | Thiol-derivatized nucleosides | ISIS PHARMACEUTICALS, INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0724447-A1 | DERIVATIZED OLIGONUCLEOTIDES HAVING IMPROVED UPTAKE AND OTHER PROPERTIES | ISIS PHARMACEUTICALS, INC. (US) | 1996-08-07 | — | — | EP | disclosed |
| EP-0716604-A1 | THIOL-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 1996-06-19 | — | — | EP | disclosed |
| WO-1996011205-A9 | PEPTIDE NUCLEIC ACID CONJUGATES | — | 1996-05-30 | — | — | WO | disclosed |
| WO-1996011205-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS, INC. (US) | 1996-04-18 | — | — | WO | disclosed |
| EP-0724447-A4 | DERIVATIZED OLIGONUCLEOTIDES HAVING IMPROVED UPTAKE AND OTHER PROPERTIES | ISIS PHARMACEUTICALS INC (US) | 1996-01-22 | — | — | EP | disclosed |
| WO-1995030670-A2 | PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-16 | — | — | WO | disclosed |
| WO-1995006474-A1 | THIOL-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 1995-03-09 | — | — | WO | disclosed |
| WO-1993007883-A1 | DERIVATIZED OLIGONUCLEOTIDES HAVING IMPROVED UPTAKE AND OTHER PROPERTIES | ISIS PHARMACEUTICALS, INC. (US) | 1993-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182038-A1 | Leptomycin Derivatives | CLSPN, CD47, HCLS1 | ALDH1A1 3948/4885MAPT 2682/4885POLB 4421/4885 |
| US-20110002947-A1 | LEPTOMYCIN DERIVATIVES | CLSPN, CD47, HCLS1 | ALDH1A1 3948/4885MAPT 2682/4885POLB 4421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.