Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.68 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | CES1 | P23141 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 3/20 | 0.59 |
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA3 | P07451 | 1/20 | 0.59 |
| ▸ | CA4 | P22748 | 1/20 | 0.59 |
| ▸ | CA6 | P23280 | 1/20 | 0.59 |
| ▸ | CA5A | P35218 | 1/20 | 0.59 |
| ▸ | CA7 | P43166 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.59 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28241270 | 1.00 | ALDH1A1 (0.68) | ALDH1A1HSD17B10ACHELMNACES1 | |
| SCHEMBL27909482 | 0.96 | ALDH1A1 (0.72) | ALDH1A1HSD17B10ACHELMNACES1 | |
| SCHEMBL22567 | 0.96 | ALDH1A1 (0.72) | ALDH1A1HSD17B10ACHELMNACES1 | |
| SCHEMBL27830410 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HSD17B10ACHELMNACES1 | |
| SCHEMBL27986433 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HSD17B10ACHELMNACES1 | |
| Hydrogen Sulfide SCHEMBL27319417 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HSD17B10ACHELMNACES1 | |
| SCHEMBL27813527 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HSD17B10ACHELMNACES1 | |
| SCHEMBL27844585 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HSD17B10ACHELMNACES1 | |
| Ammonia Solution, Strong SCHEMBL27511010 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HSD17B10ACHELMNACES1 | |
| Water SCHEMBL28670631 | 0.91 | CA1 (0.64) | ALDH1A1HSD17B10ACHELMNACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102249934-A | Diamino-alcohol compounds and processes for their manufacture | DOW GLOBAL TECHNOLOGIES LLC | 2011-11-23 | — | — | CN | claimed |
| CN-102250548-B | Novel diamino-alcohol compounds, their manufacture and use in coatings applications | DOW GLOBAL TECHNOLOGIES LLC | 2014-06-25 | — | — | CN | disclosed |
| CN-102249607-B | Novel diamino-alcohol compounds, manufacture and use thereof in high solids mineral slurries | DOW GLOBAL TECHNOLOGIES LLC | 2013-11-13 | — | — | CN | disclosed |
| CN-102181044-B | Novel diamino-alcohol compounds, their manufacture and use in epoxy resins | DOW GLOBAL TECHNOLOGIES INC | 2013-07-10 | — | — | CN | disclosed |
| CN-102249607-A | Novel diamino-alcohol compounds, their manufacture and use in high solids mineral slurries | DOW GLOBAL TECHNOLOGIES LLC | 2011-11-23 | — | — | CN | disclosed |
| CN-102250548-A | Novel diamino-alcohol compounds, their manufacture and use in coatings applications | DOW GLOBAL TECHNOLOGIES LLC | 2011-11-23 | — | — | CN | disclosed |
| CN-102249934-A | Diamino-alcohol compounds and processes for their manufacture | DOW GLOBAL TECHNOLOGIES LLC | 2011-11-23 | — | — | CN | disclosed |
| CN-102181044-A | Novel diamino-alcohol compounds, their manufacture and use in epoxy resins | DOW GLOBAL TECHNOLOGIES INC | 2011-09-14 | — | — | CN | disclosed |
| CN-1036394-C | Process for preparing quinolone derivatives | OTSUKA PHARMA CO LTD (JP) | 1997-11-12 | — | — | CN | disclosed |