Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.50 |
| ▸ | BCHE | P06276 | 4/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9254634 | 0.90 | MAOB (0.51) | ACHEBCHECHRM4MAOBMAOA | |
| SCHEMBL9261890 | 0.85 | ACHE (0.51) | ACHEBCHECHRM4MAOBMAOA | |
| SCHEMBL9259505 | 0.76 | KDM4E (0.51) | — | |
| SCHEMBL9260014 | 0.74 | CNR1 (0.56) | ACHEBCHECHRM4MAOBMAOA | |
| SCHEMBL7593860 | 0.70 | ACHE (0.54) | ACHEBCHE | |
| SCHEMBL9260634 | 0.70 | ACHE (0.54) | ACHEBCHECHRM4MAOBMAOA | |
| SCHEMBL9251113 | 0.70 | ACHE (0.54) | ACHEBCHECHRM4MAOBMAOA | |
| SCHEMBL9251812 | 0.70 | ACHE (0.64) | ACHEBCHECHRM4MAOBMAOA | |
| SCHEMBL220628 | 0.69 | ACHE (0.58) | ACHEBCHE | |
| SCHEMBL4591300 | 0.69 | DRD2 (0.52) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |