Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753625 | 0.80 | CA12 (0.53) | LMNAL3MBTL1CYP2D6CYP2C19KDM4E | |
| SCHEMBL11338231 | 0.79 | CYP2D6 (0.47) | LMNAL3MBTL1CYP2D6CYP2C19KDM4E | |
| SCHEMBL6988798 | 0.78 | CYP2D6 (0.46) | LMNAL3MBTL1CYP2D6CYP2C19KDM4E | |
| SCHEMBL2680385 | 0.78 | CYP2D6 (0.46) | LMNAL3MBTL1CYP2D6CYP2C19KDM4E | |
| SCHEMBL2741387 | 0.76 | MGLL (0.53) | LMNAL3MBTL1CYP2D6CYP2C19KDM4E | |
| SCHEMBL12574808 | 0.75 | CYP2D6 (0.43) | LMNAL3MBTL1CYP2D6CYP2C19KDM4E | |
| Dimethylamine SCHEMBL28560259 | 0.72 | CYP2C19 (0.52) | LMNAL3MBTL1CYP2D6CYP2C19KDM4E | |
| SCHEMBL14344896 | 0.72 | CYP2D6 (0.47) | LMNACYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL243741 | 0.72 | POLB (0.51) | LMNAL3MBTL1CYP2D6CYP2C19KDM4E | |
| SCHEMBL762423 | 0.72 | ALDH1A1 (0.50) | LMNAL3MBTL1CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378706-A | Memory disorders, senile dememtia | SANOFI (FR) | 1995-01-03 | — | — | US | disclosed |
| US-5232921-A | Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions | SANOFI (FR) | 1993-08-03 | — | — | US | disclosed |