Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.58 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.58 |
| ▸ | BHMT | Q93088 | 3/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9264322 | 1.00 | LMNA (0.64) | LMNAHSD17B10KMT2ATDP1GPR84 | |
| SCHEMBL8176355 | 0.91 | GPR84 (0.73) | LMNAHSD17B10KMT2ATDP1GPR84 | |
| SCHEMBL8651227 | 0.91 | GPR84 (0.73) | LMNAHSD17B10KMT2ATDP1GPR84 | |
| SCHEMBL8650019 | 0.91 | GPR84 (0.73) | LMNAHSD17B10KMT2ATDP1GPR84 | |
| SCHEMBL9262544 | 0.91 | GPR84 (0.73) | LMNAHSD17B10KMT2ATDP1GPR84 | |
| SCHEMBL8650879 | 0.91 | GPR84 (0.73) | LMNAHSD17B10KMT2ATDP1GPR84 | |
| SCHEMBL9264906 | 0.91 | GPR84 (0.73) | LMNAHSD17B10KMT2ATDP1GPR84 | |
| SCHEMBL3913691 | 0.91 | LMNA (0.70) | LMNAHSD17B10KMT2ATDP1GPR84 | |
| SCHEMBL10567294 | 0.91 | LMNA (0.78) | LMNAHSD17B10KMT2ATDP1GPR84 | |
| SCHEMBL2596733 | 0.86 | GPR84 (0.65) | LMNAHSD17B10KMT2ATDP1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391564-A | E.g., rhizoxin-13-yl 3-methylthiopropionate; anticarcinogenic agents | SANKYO COMPANY, LIMITED (JP) | 1995-02-21 | — | — | US | disclosed |
| US-5352689-A | Rhizoxin derivatives and their use as anti-tumor agents | SANKYO COMPANY, LIMITED (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0350315-B1 | RHIZOXIN DERIVATES AND THEIR USE AS ANTI-TUMOR AGENTS | SANKYO COMPANY LIMITED (JP) | 1993-06-16 | — | — | EP | disclosed |
| EP-0350315-A1 | Rhizoxin derivates and their use as anti-tumor agents | SANKYO COMPANY LIMITED (JP) | 1990-01-10 | — | — | EP | disclosed |