Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9263101 | 0.85 | RAPGEF4 (0.47) | RAPGEF4SMN1; SMN2GAAMAPTTP53 | |
| SCHEMBL4174907 | 0.81 | RAPGEF4 (0.39) | RAPGEF4SMN1; SMN2GAAMAPTTP53 | |
| SCHEMBL9598092 | 0.70 | RAPGEF4 (0.49) | RAPGEF4GAAPKMESR1HTR6 | |
| SCHEMBL7266691 | 0.69 | RAPGEF4 (0.38) | RAPGEF4SMN1; SMN2GAAMAPTTP53 | |
| SCHEMBL9266453 | 0.68 | GAA (0.40) | RAPGEF4SMN1; SMN2GAAMAPTPKM | |
| SCHEMBL7266582 | 0.65 | HSD11B1 (0.62) | RAPGEF4GAAPKMESR1ENPP2 | |
| SCHEMBL9599177 | 0.64 | RAPGEF4 (0.41) | RAPGEF4GAAPKMESR1ENPP2 | |
| SCHEMBL29227532 | 0.64 | ALDH1A1 (0.56) | RAPGEF4SMN1; SMN2GAAMAPTPKM | |
| SCHEMBL11188982 | 0.63 | RAPGEF4 (1.00) | RAPGEF4GAAMAPTPKMENPP2 | |
| SCHEMBL9460121 | 0.63 | HSD11B1 (0.59) | RAPGEF4GAAPKMESR1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5444056-A | Hypotensive agnets, calcium channel blockers | SANOFI (FR) | 1995-08-22 | — | — | US | disclosed |