Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260957 | 0.87 | AKR1C3 (0.55) | AKR1C3AKR1C2PDK2LMNAPTGS1 | |
| SCHEMBL9261492 | 0.81 | LMNA (0.38) | AKR1C3AKR1C2PDK2LMNANR1H3 | |
| SCHEMBL9257716 | 0.78 | HSD11B1 (0.43) | PDK2LMNAALDH1A1TSHRTDP1 | |
| SCHEMBL17123654 | 0.77 | CYP2D6 (0.38) | AKR1C3AKR1C2PDK2LMNATRPA1 | |
| SCHEMBL12220280 | 0.76 | FFAR1 (0.51) | AKR1C3AKR1C2FFAR1 | |
| SCHEMBL24910320 | 0.75 | AKR1C3 (0.51) | AKR1C3AKR1C2PDK2LMNAPTPN5 | |
| SCHEMBL24910037 | 0.74 | AKR1C3 (0.55) | AKR1C3AKR1C2PDK2LMNATRPA1 | |
| SCHEMBL24910185 | 0.74 | AKR1C3 (0.51) | AKR1C3AKR1C2PDK2LMNAPTPN5 | |
| SCHEMBL9289969 | 0.74 | ALOX5AP (0.39) | PDK2LMNANR1H3CRHR1GRIA4 | |
| SCHEMBL13524522 | 0.74 | LMNA (0.50) | AKR1C3AKR1C2PDK2LMNAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120135997-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND | SHIONOGI & CO., LTD. (JP) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135997-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND | BACE1, STS, APP | AKR1C3 2800/4885AKR1C2 3182/4885PDK2 4082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.