Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 9/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | FABP2 | P12104 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260944 | 0.87 | AKR1C3 (0.42) | AKR1C3AKR1C2PDK2PTGS1LMNA | |
| SCHEMBL12570870 | 0.83 | AKR1C3 (0.48) | AKR1C3AKR1C2PDK2PTGS1MEN1 | |
| SCHEMBL9261492 | 0.77 | LMNA (0.38) | AKR1C3AKR1C2PDK2PTGS1MEN1 | |
| SCHEMBL24910037 | 0.77 | AKR1C3 (0.55) | AKR1C3AKR1C2PDK2LMNATSHR | |
| SCHEMBL10267400 | 0.77 | LMNA (0.38) | AKR1C3AKR1C2PDK2PTGS1LMNA | |
| SCHEMBL19393147 | 0.77 | AKR1C3 (0.47) | AKR1C3AKR1C2PDK2PTGS1MEN1 | |
| SCHEMBL22346200 | 0.75 | ALDH1A1 (0.46) | AKR1C3AKR1C2PDK2PTGS1MEN1 | |
| SCHEMBL24910239 | 0.75 | AKR1C3 (0.55) | AKR1C3AKR1C2PDK2LMNATSHR | |
| SCHEMBL16075900 | 0.74 | AKR1C3 (0.70) | AKR1C3AKR1C2PDK2PTGS1MEN1 | |
| SCHEMBL9289363 | 0.74 | ALOX5AP (0.45) | AKR1C3AKR1C2PDK2PTGS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120135997-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND | SHIONOGI & CO., LTD. (JP) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135997-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND | BACE1, STS, APP | AKR1C3 2800/4885AKR1C2 3182/4885PDK2 4082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.