Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9474057 | 0.81 | LTA4H (0.47) | — | |
| SCHEMBL10774498 | 0.78 | POLB (0.66) | POLBEPHX2HTTSRD5A2SMN1; SMN2 | |
| SCHEMBL9502056 | 0.78 | TTR (0.37) | SMN1; SMN2ALDH1A1KDM4ENPC1MAPT | |
| SCHEMBL920207 | 0.78 | ST14 (0.53) | MAOBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9473089 | 0.78 | ST14 (0.32) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL9473514 | 0.75 | CA12 (0.50) | POLBL3MBTL1HTTALDH1A1LMNA | |
| SCHEMBL11237117 | 0.72 | MTNR1A (0.54) | POLBL3MBTL1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL9262585 | 0.72 | HTT (0.59) | POLBHTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL850542 | 0.72 | SRD5A2 (0.62) | POLBEPHX2SRD5A2ALDH1A1MAPK14 | |
| SCHEMBL2367221 | 0.70 | POLB (0.56) | POLBEPHX2L3MBTL1MAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5403934-A | Heterocyclic compounds | BURROUGHS WELLCOME CO. (US) | 1995-04-04 | — | — | US | disclosed |
| WO-1991013873-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-09-19 | — | — | WO | disclosed |
| EP-0447164-A1 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-09-18 | — | — | EP | disclosed |