SCHEMBL920207

SCHEMBL920207

Cc1csc(Oc2ccc(CN)cc2)c1

nearest known ligand 0.53

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ST14 Q9Y5Y6 3/20 0.53
MAOB P27338 7/20 0.38
KEAP1 Q14145 1/20 0.38
NFE2L2 Q16236 1/20 0.38
MMP2 P08253 5/20 0.36
MMP9 P14780 5/20 0.36
MMP8 P22894 5/20 0.36
MMP14 P50281 5/20 0.36
ALDH1A1 P00352 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL920837 0.85 F10 (0.42) ST14MAOBALDH1A1
SCHEMBL9474279 0.83 ST14 (0.50) ST14MAOBKEAP1NFE2L2MMP2
SCHEMBL9473089 0.83 ST14 (0.32) ST14ALDH1A1SMN1; SMN2
SCHEMBL9502056 0.83 TTR (0.37) ST14ALDH1A1SMN1; SMN2
SCHEMBL9474057 0.83 LTA4H (0.47) ST14MMP2MMP9MMP14
SCHEMBL4730671 0.80 ALDH1A1 (0.57) MAOBALDH1A1SMN1; SMN2
SCHEMBL9260947 0.78 POLB (0.47) MAOBALDH1A1SMN1; SMN2
SCHEMBL920927 0.75 ST14 (0.68) ST14MAOBKEAP1NFE2L2MMP2
SCHEMBL9473980 0.74 SLC6A4 (0.40) ALDH1A1SMN1; SMN2
SCHEMBL920355 0.74 ST14 (0.73) ST14MAOBKEAP1NFE2L2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994005642-A1 INDAZOLE DERIVATIVES CIBA-GEIGY AG (CH) 1994-03-17 WO claimed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed
WO-1994005642-A1 INDAZOLE DERIVATIVES CIBA-GEIGY AG (CH) 1994-03-17 WO disclosed
US-5264448-A Thioamides, oxazole ring, insecticides, miticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-11-23 US disclosed
US-5206259-A Insecticides, acaricides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-04-27 US disclosed
EP-0394043-A1 An amide compound and its production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1990-10-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 ST14 708/4885MAOB 3730/4885KEAP1 521/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.