Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TACR2 | P21452 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259670 | 0.86 | HRH1 (0.69) | TACR2TACR1HRH1 | |
| SCHEMBL9260920 | 0.85 | KDM4E (0.50) | KDM4EHSD17B10APEX1PTGDR2ALDH1A1 | |
| SCHEMBL9253881 | 0.85 | HRH1 (0.58) | KDM4ETACR2TACR1HRH1 | |
| SCHEMBL9268629 | 0.84 | HRH1 (0.45) | KDM4ETACR2TACR1HRH1HSD17B10 | |
| SCHEMBL9267223 | 0.84 | HRH1 (0.47) | KDM4ETACR2TACR1HRH1HSD17B10 | |
| SCHEMBL9268450 | 0.82 | TACR2 (0.77) | TACR2TACR1HRH1PTGDR2MEN1 | |
| SCHEMBL9268872 | 0.79 | TACR2 (0.44) | KDM4ETACR2TACR1HRH1HSD17B10 | |
| SCHEMBL9268456 | 0.78 | TACR2 (0.53) | KDM4ETACR2TACR1HRH1PTGDR2 | |
| SCHEMBL9268866 | 0.78 | HRH1 (0.43) | KDM4ETACR2TACR1HRH1HSD17B10 | |
| SCHEMBL9268763 | 0.77 | HRH1 (0.42) | TACR2TACR1HRH1OPRL1OGFRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380731-A | Antiallergic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0561973-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| WO-1992010491-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-25 | — | — | WO | disclosed |