Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.42 |
| ▸ | TACR2 | P21452 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | OGFRL1 | Q5TC84 | 6/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9258971 | 0.83 | HRH1 (0.42) | HRH1TACR2TACR1 | |
| SCHEMBL9258620 | 0.83 | TACR2 (0.36) | HRH1TACR2TACR1OGFRL1OPRM1 | |
| SCHEMBL9259444 | 0.83 | STS (0.45) | OGFRL1OPRM1OPRD1OPRK1KMT2A | |
| SCHEMBL9268872 | 0.83 | TACR2 (0.44) | HRH1TACR2TACR1MEN1KMT2A | |
| SCHEMBL9260978 | 0.77 | KDM4E (0.50) | HRH1TACR2TACR1OGFRL1OPRL1 | |
| SCHEMBL9268748 | 0.74 | HRH1 (0.41) | HRH1TACR2TACR1OGFRL1OPRM1 | |
| SCHEMBL9260561 | 0.73 | HRH1 (0.39) | HRH1TACR2TACR1OGFRL1OPRM1 | |
| SCHEMBL9258366 | 0.72 | HRH1 (0.63) | HRH1TACR2TACR1CYP2D6 | |
| SCHEMBL9260703 | 0.71 | HRH1 (0.42) | HRH1TACR2TACR1 | |
| SCHEMBL9259670 | 0.70 | HRH1 (0.69) | HRH1TACR2TACR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380731-A | Antiallergic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0561973-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| WO-1992010491-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-25 | — | — | WO | disclosed |