Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 9/20 | 0.52 |
| ▸ | KDR | P35968 | 9/20 | 0.52 |
| ▸ | MIF | P14174 | 1/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13336370 | 0.87 | KDR (0.61) | FGFR3KDRFLT3 | |
| SCHEMBL72789 | 0.81 | FYN (0.63) | FGFR3KDRCDK2KDM4EALDH1A1 | |
| SCHEMBL72363 | 0.78 | IRAK4 (0.61) | FGFR3KDRMIFIRAK4FLT3 | |
| SCHEMBL73833 | 0.76 | FGFR3 (0.73) | FGFR3KDR | |
| SCHEMBL72956 | 0.75 | CDK2 (0.60) | FGFR3KDRMIFIRAK4IKBKE | |
| SCHEMBL13336412 | 0.74 | KDR (0.47) | FGFR3KDRALDH1A1 | |
| SCHEMBL22044100 | 0.74 | KIT (0.58) | FGFR3KDRMIFIRAK4IKBKE | |
| SCHEMBL73445 | 0.74 | MIF (0.60) | KDRMIFIRAK4IKBKETBK1 | |
| SCHEMBL72990 | 0.74 | MIF (0.48) | FGFR3KDRMIFIRAK4IKBKE | |
| SCHEMBL71926 | 0.73 | FGFR3 (0.77) | FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |