Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9261883 | 0.86 | ACHE (0.49) | ACHEBCHEMEN1POLBKMT2A | |
| SCHEMBL9260356 | 0.77 | ALDH1A1 (0.48) | ACHEBCHEBACE1DRD4 | |
| SCHEMBL9258180 | 0.77 | ACHE (0.52) | ACHEBCHEBACE1DRD4 | |
| SCHEMBL9844722 | 0.76 | ACHE (0.46) | ACHEBCHEDRD2DRD4 | |
| SCHEMBL9264004 | 0.75 | ACHE (0.50) | ACHEBACE1KMT2A | |
| SCHEMBL9264009 | 0.75 | ACHE (0.50) | ACHEBACE1KMT2A | |
| SCHEMBL9262810 | 0.74 | BCHE (0.51) | ACHEBCHEBACE1DRD2DRD4 | |
| SCHEMBL9265158 | 0.70 | ACHE (0.48) | ACHEBACE1DRD2 | |
| SCHEMBL9262922 | 0.70 | ACHE (0.52) | ACHEBCHEBACE1DRD4 | |
| SCHEMBL9265528 | 0.69 | ACHE (0.44) | ACHEBCHEBACE1MAOADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | claimed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | claimed |
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |