Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9258751 | 0.89 | ACHE (0.48) | ACHECCR3 | |
| SCHEMBL9262802 | 0.76 | ACHE (0.49) | ACHEBCHEDRD2DRD4 | |
| SCHEMBL27347756 | 0.74 | CCR3 (0.44) | ACHECCR3DRD2DRD4 | |
| SCHEMBL9264946 | 0.73 | ACHE (0.48) | ACHEBCHEDRD4KDM4E | |
| SCHEMBL9261883 | 0.72 | ACHE (0.49) | ACHEBCHEDRD2DRD4 | |
| SCHEMBL9844725 | 0.69 | CCR3 (0.54) | ACHECCR3DRD2DRD4ALDH1A1 | |
| SCHEMBL8531462 | 0.67 | KDM4E (0.48) | ACHEBCHEDRD2DRD4ALDH1A1 | |
| SCHEMBL9264959 | 0.67 | BCHE (0.48) | ACHEBCHEDRD4KDM4E | |
| SCHEMBL12813632 | 0.67 | KDM1A (0.61) | ACHECCR3BCHEDRD2ALDH1A1 | |
| SCHEMBL2735346 | 0.66 | CCR3 (0.71) | ACHECCR3DRD2DRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |