Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LDHA | P00338 | 13/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL92986 | 0.86 | LMNA (0.59) | LMNAGAAKMT2ALDHAALDH1A1 | |
| SCHEMBL9264609 | 0.83 | LMNA (0.56) | LMNAGAAKMT2ALDHAALDH1A1 | |
| SCHEMBL10808024 | 0.82 | LMNA (0.55) | LMNAGAAKMT2ALDHAALDH1A1 | |
| SCHEMBL1129788 | 0.79 | LMNA (0.63) | LMNAGAAKMT2ALDHAALDH1A1 | |
| SCHEMBL20446813 | 0.79 | LMNA (0.55) | LMNAGAAKMT2ALDHAALDH1A1 | |
| SCHEMBL31447811 | 0.77 | LMNA (0.60) | LMNAGAAKMT2ALDHAALDH1A1 | |
| SCHEMBL10808372 | 0.74 | LMNA (0.44) | LMNAGAAKMT2ALDHAALDH1A1 | |
| SCHEMBL2466435 | 0.74 | LMNA (0.56) | LMNAGAAKMT2ALDHAALDH1A1 | |
| SCHEMBL21261241 | 0.73 | LMNA (0.56) | LMNAGAAKMT2ALDHAALDH1A1 | |
| SCHEMBL7100551 | 0.72 | LMNA (0.54) | LMNAGAAKMT2ALDHAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430042-A | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use | AKTIEBOLAGET ASTRA (SE) | 1995-07-04 | — | — | US | disclosed |
| EP-0593463-A1 | DIALKOXY-PYRIDINYL-BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | AKTIEBOLAGET ASTRA (SE) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019712-A1 | DIALKOXY-PYRIDINYL-BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | AKTIEBOLAGET ASTRA (SE) | 1991-12-26 | — | — | WO | disclosed |