Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.66 |
| ▸ | PRKCA | P17252 | 3/20 | 0.66 |
| ▸ | MAP3K9 | P80192 | 3/20 | 0.66 |
| ▸ | GLI1 | P08151 | 2/20 | 0.66 |
| ▸ | GLI2 | P10070 | 2/20 | 0.66 |
| ▸ | CDK4 | P11802 | 2/20 | 0.66 |
| ▸ | CCND1 | P24385 | 2/20 | 0.66 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.66 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.66 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.66 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.66 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.66 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.66 |
| ▸ | PRKCG | P05129 | 1/20 | 0.66 |
| ▸ | PRKCB | P05771 | 1/20 | 0.66 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.66 |
| ▸ | PRKACA | P17612 | 1/20 | 0.66 |
| ▸ | PRKACG | P22612 | 1/20 | 0.66 |
| ▸ | PRKACB | P22694 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9270827 | 0.94 | MAP3K11 (0.78) | MAP3K11PRKCAMAP3K9GLI1GLI2 | |
| SCHEMBL9263371 | 0.94 | MAP3K11 (0.78) | MAP3K11PRKCAMAP3K9GLI1GLI2 | |
| SCHEMBL9265092 | 0.89 | PARP1 (0.75) | MAP3K11PRKCAMAP3K9GLI1GLI2 | |
| SCHEMBL22567012 | 0.83 | MAP3K11 (0.66) | MAP3K11PRKCAMAP3K9GLI1GLI2 | |
| Staurosporinone SCHEMBL29389399 | 0.80 | MAP3K11 (1.00) | MAP3K11PRKCAMAP3K9GLI1GLI2 | |
| Staurosporinone SCHEMBL29374983 | 0.80 | MAP3K11 (1.00) | MAP3K11PRKCAMAP3K9GLI1GLI2 | |
| Staurosporinone SCHEMBL5440281 | 0.80 | MAP3K11 (1.00) | MAP3K11PRKCAMAP3K9GLI1GLI2 | |
| SCHEMBL9545490 | 0.75 | ROCK2 (0.88) | MAP3K11PRKCAMAP3K9GLI1GLI2 | |
| SCHEMBL9266338 | 0.75 | PARP1 (0.75) | MAP3K11PRKCAMAP3K9GLI1GLI2 | |
| SCHEMBL22567014 | 0.75 | ROCK2 (0.71) | MAP3K11PRKCAMAP3K9GLI1GLI2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5438050-A | Indolocarbazole derivatives, processes for their preparation and compositions containing them | GODECKE AKTIENGESELLSCHAFT (DE) | 1995-08-01 | — | — | US | disclosed |
| EP-0370236-B1 | INDOLOCARBAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1991-12-27 | — | — | EP | disclosed |
| EP-0370236-A1 | Indolocarbazole derivatives, processes for their preparation and their use as medicaments | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |