Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 13/20 | 0.57 |
| ▸ | TACR2 | P21452 | 1/20 | 0.57 |
| ▸ | TACR1 | P25103 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9541656 | 0.89 | HRH1 (0.61) | HRH1TACR2TACR1CYP2D6KCNH2 | |
| SCHEMBL9544433 | 0.88 | HRH1 (0.58) | HRH1TACR2TACR1CYP2D6KCNH2 | |
| SCHEMBL9264751 | 0.87 | HRH1 (0.72) | HRH1TACR2TACR1CYP2D6KCNH2 | |
| SCHEMBL9259609 | 0.77 | HRH1 (0.67) | HRH1TACR2TACR1CYP2D6KCNH2 | |
| SCHEMBL9258632 | 0.77 | HRH1 (0.56) | HRH1CYP2D6KCNH2CHRM1TP53 | |
| SCHEMBL10529762 | 0.76 | SSTR5 (0.78) | HRH1TACR2TACR1CYP2D6KCNH2 | |
| SCHEMBL9196229 | 0.76 | HRH1 (0.66) | HRH1TACR2TACR1CYP2D6KCNH2 | |
| SCHEMBL9697152 | 0.76 | HRH1 (0.73) | HRH1TACR2TACR1CYP2D6KCNH2 | |
| SCHEMBL9543194 | 0.74 | HRH1 (0.56) | HRH1CYP2D6KCNH2CHRM1TP53 | |
| SCHEMBL9259670 | 0.74 | HRH1 (0.69) | HRH1TACR2TACR1CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993014083-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-22 | — | — | WO | disclosed |