Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.81 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.81 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.81 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 2/20 | 0.64 |
| ▸ | FAAH | O00519 | 1/20 | 0.64 |
| ▸ | BCHE | P06276 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | YWHAB | P31946 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770486 | 0.91 | PTPN1 (0.78) | HPGDABCB1ABCG2PTPN1SMN1; SMN2 | |
| SCHEMBL20816070 | 0.86 | KDM4E (0.76) | HPGDABCB1ABCG2PTPN1SMN1; SMN2 | |
| SCHEMBL9273628 | 0.85 | KMT2A (0.82) | HPGDSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL9273340 | 0.83 | KMT2A (0.84) | HPGDABCB1ABCG2SMN1; SMN2NPC1 | |
| SCHEMBL4737461 | 0.83 | MEN1 (0.78) | HPGDABCB1ABCG2PTPN1SMN1; SMN2 | |
| SCHEMBL17117490 | 0.82 | KMT2A (0.67) | HPGDABCB1ABCG2PTPN1NPC1 | |
| SCHEMBL11470220 | 0.81 | PTPN1 (0.73) | HPGDABCB1ABCG2PTPN1SMN1; SMN2 | |
| SCHEMBL28650889 | 0.81 | PTPN1 (0.61) | HPGDABCB1ABCG2PTPN1ACHE | |
| SCHEMBL17117372 | 0.81 | HPGD (0.65) | HPGDABCB1ABCG2PTPN1MAPT | |
| SCHEMBL29177626 | 0.80 | SMN1; SMN2 (0.63) | HPGDABCB1ABCG2PTPN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995029155-A1 | NOVEL ANTITUMOUR COMPOUNDS WITH ANTIMITOTIC ACTIVITY | PHARMACIA AB (SE) | 1995-11-02 | — | — | WO | disclosed |