Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.60 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.58 |
| ▸ | CASP2 | P42575 | 1/20 | 0.53 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 3/20 | 0.52 |
| ▸ | PPARD | Q03181 | 3/20 | 0.52 |
| ▸ | PPARA | Q07869 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.52 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.52 |
| ▸ | TLR2 | O60603 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009655 | 1.00 | MEN1 (0.71) | MEN1KMT2AADRA1APRMT1EPHX2 | |
| SCHEMBL19400283 | 1.00 | MEN1 (0.71) | MEN1KMT2AADRA1APRMT1EPHX2 | |
| SCHEMBL5522638 | 1.00 | MEN1 (0.71) | MEN1KMT2AADRA1APRMT1EPHX2 | |
| SCHEMBL19400289 | 1.00 | MEN1 (0.71) | MEN1KMT2AADRA1APRMT1EPHX2 | |
| SCHEMBL45902 | 0.98 | MEN1 (0.74) | MEN1KMT2AADRA1APRMT1EPHX2 | |
| SCHEMBL1912627 | 0.91 | MEN1 (0.70) | MEN1KMT2AADRA1APRMT1EPHX2 | |
| SCHEMBL9259257 | 0.87 | MEN1 (0.94) | MEN1KMT2ACASP2ALDH1A1 | |
| SCHEMBL21765846 | 0.87 | MEN1 (0.94) | MEN1KMT2ACASP2ALDH1A1 | |
| SCHEMBL11758762 | 0.87 | MEN1 (0.94) | MEN1KMT2ACASP2ALDH1A1 | |
| SCHEMBL9262199 | 0.86 | CASP2 (0.74) | MEN1KMT2AADRA1APRMT1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391564-A | E.g., rhizoxin-13-yl 3-methylthiopropionate; anticarcinogenic agents | SANKYO COMPANY, LIMITED (JP) | 1995-02-21 | — | — | US | disclosed |
| US-5352689-A | Rhizoxin derivatives and their use as anti-tumor agents | SANKYO COMPANY, LIMITED (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0350315-B1 | RHIZOXIN DERIVATES AND THEIR USE AS ANTI-TUMOR AGENTS | SANKYO COMPANY LIMITED (JP) | 1993-06-16 | — | — | EP | disclosed |
| EP-0350315-A1 | Rhizoxin derivates and their use as anti-tumor agents | SANKYO COMPANY LIMITED (JP) | 1990-01-10 | — | — | EP | disclosed |