SCHEMBL9267263

SCHEMBL9267263

CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2COC2)CC1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.67
KDM4E B2RXH2 8/20 0.67
HPGD P15428 5/20 0.66
LMNA P02545 4/20 0.66
HSD17B10 Q99714 4/20 0.66
MAPT P10636 1/20 0.66
DRD3 P35462 1/20 0.65
CYP1A2 P05177 1/20 0.64
TOP2A P11388 1/20 0.64
CYP2C9 P11712 1/20 0.64
TOP2B Q02880 1/20 0.64
MEN1 O00255 2/20 0.62
KMT2A Q03164 2/20 0.62
NPC1 O15118 1/20 0.60
PIK3CG P48736 5/20 0.55
PIK3CD O00329 3/20 0.55
PIK3R1 P27986 3/20 0.55
PIK3CA P42336 3/20 0.55
HTT P42858 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29576608 0.91 ALDH1A1 (0.81) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL2780752 0.91 ALDH1A1 (0.81) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL9268053 0.88 ALDH1A1 (0.67) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL9265472 0.88 ALDH1A1 (0.70) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL9260339 0.84 ALDH1A1 (0.66) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL9260344 0.84 ALDH1A1 (0.66) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL14471237 0.84 ALDH1A1 (0.74) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL8131494 0.83 KDM4E (0.56) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL11394177 0.82 ALDH1A1 (0.76) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL13694077 0.82 ALDH1A1 (0.71) ALDH1A1KDM4EHPGDLMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5407932-A Bactericides WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1995-04-18 US disclosed
EP-0393400-B1 Novel quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same WAKUNAGA SEIYAKU KK (JP) 1994-12-21 EP disclosed
US-5245037-A Synthetic bactericides WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1993-09-14 US disclosed
EP-0393400-A1 Novel quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1990-10-24 EP disclosed