Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.74 |
| ▸ | NSD2 | O96028 | 3/20 | 0.74 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.74 |
| ▸ | ABL1 | P00519 | 1/20 | 0.74 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.74 |
| ▸ | CES1 | P23141 | 1/20 | 0.74 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | THRB | P10828 | 1/20 | 0.74 |
| ▸ | BLM | P54132 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | PTPRC | P08575 | 2/20 | 0.72 |
| ▸ | CTSL | P07711 | 1/20 | 0.72 |
| ▸ | CTSS | P25774 | 1/20 | 0.72 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.72 |
| ▸ | S100A4 | P26447 | 6/20 | 0.67 |
| ▸ | CDC25B | P30305 | 3/20 | 0.67 |
| ▸ | PADI1 | Q9ULC6 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5915065 | 0.95 | TDP2 (0.81) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL460626 | 0.93 | TDP2 (0.78) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL29746876 | 0.88 | GAA (0.78) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL1103717 | 0.88 | GAA (0.78) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL5915061 | 0.88 | GAA (0.86) | TDP2NSD2PAX8ABL1PLCG1 | |
| Phanquone SCHEMBL462025 | 0.85 | MEN1 (1.00) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL460433 | 0.85 | TDP2 (1.00) | TDP2NSD2PAX8ABL1PLCG1 | |
| Phanquone SCHEMBL30956643 | 0.85 | MEN1 (1.00) | TDP2NSD2PAX8ABL1PLCG1 | |
| Phanquone SCHEMBL7633567 | 0.85 | MEN1 (1.00) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL30774319 | 0.85 | GAA (1.00) | TDP2NSD2PAX8ABL1PLCG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434264-A | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-07-18 | — | — | US | disclosed |
| US-5300642-A | α, α-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-04-05 | — | — | US | disclosed |
| EP-0311010-B1 | Alpha,Alpha-disubstituted aromatics and heteroaromatics as cognition enhancers | DU PONT MERCK PHARMA (US) | 1994-02-02 | — | — | EP | disclosed |
| EP-0532054-A1 | Process for preparing alpha,alpha-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| US-5173489-A | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DUPONT MERCK PHARMACEUTICAL CO. (US) | 1992-12-22 | — | — | US | disclosed |
| EP-0311010-A2 | Alpha,Alpha-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1989-04-12 | — | — | EP | disclosed |