Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL8887498 | 0.93 | KDM4E (0.35) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL11830480 | 0.93 | P2RX4 (0.33) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Oxalic Acid SCHEMBL10499933 | 0.87 | MEN1 (0.32) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL244606 | 0.86 | KDM4E (0.37) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Acetic Acid SCHEMBL25341096 | 0.85 | TRPA1 (0.31) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL8480733 | 0.84 | KDM4E (0.36) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL29757278 | 0.84 | KDM4E (0.36) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Methylene Chloride SCHEMBL27481165 | 0.83 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Fumaric Acid SCHEMBL11602682 | 0.83 | ALDH1A1 (0.38) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Fumaric Acid SCHEMBL11602668 | 0.83 | ALDH1A1 (0.38) | KDM4EMEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5449674-A | Prostaglandin E2 inhibitors | G. D. SEARLE & CO. (US) | 1995-09-12 | — | — | US | disclosed |
| EP-0613472-A1 | 10-ACYL-DIBENZ(B,F) (1,4)-OXAZEPINES AND THEIR THIAZEPINES ANALO GUES USEFUL AS PROSTAGLANDIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993009104-A1 | 10-ACYL-DIBENZ(B,F) (1,4)-OXAZEPINES AND THEIR THIAZEPINES ANALO GUES USEFUL AS PROSTAGLANDIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | disclosed |