Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.42 |
| ▸ | HTR1B | P28222 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9266960 | 0.78 | HTR1A (0.43) | HTR1AHTR1BDRD2HTR2ADRD1 | |
| SCHEMBL8554768 | 0.68 | HTR1A (0.45) | HTR1AHTR1BDRD2HTR2ADRD1 | |
| SCHEMBL8556814 | 0.67 | HTR1A (0.45) | HTR1AHTR1BDRD2HTR2ADRD1 | |
| SCHEMBL25053744 | 0.64 | HTR1A (0.37) | HTR1AHTR2AACHE | |
| SCHEMBL19301904 | 0.63 | CREBBP (0.45) | ACHE | |
| SCHEMBL30116234 | 0.63 | CREBBP (0.45) | ACHE | |
| SCHEMBL5761730 | 0.62 | KDM4E (0.46) | HTR1AHTR1BDRD2HTR2AACHE | |
| SCHEMBL4839911 | 0.61 | DRD2 (0.54) | HTR1AHTR1BDRD2HTR2ADRD1 | |
| SCHEMBL8886915 | 0.61 | HTR1A (0.54) | HTR1AHTR1BDRD2HTR2AACHE | |
| SCHEMBL9441617 | 0.61 | HTR1A (0.54) | HTR1AHTR1BDRD2HTR2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420150-A | Antidepressants and treatment of anxiety | GUILLAUMET GERALD (FR) | 1995-05-30 | — | — | US | disclosed |
| US-5397783-A | Antidepressants, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1995-03-14 | — | — | US | disclosed |
| US-5376661-A | Psychological disorders | ADIR ET COMPAGNIE (FR) | 1994-12-27 | — | — | US | disclosed |