Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.45 |
| ▸ | HTR1B | P28222 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554768 | 0.96 | HTR1A (0.45) | HTR1AHTR1BDRD2HTR2ADRD1 | |
| Hydrochloric Acid SCHEMBL7824632 | 0.75 | ADRA2A (0.58) | DRD2DRD1ADRA2A | |
| SCHEMBL8594984 | 0.74 | ALDH1A1 (0.39) | HTR1AHTR1BDRD2HTR2ADRD1 | |
| SCHEMBL9266960 | 0.73 | HTR1A (0.43) | HTR1AHTR1BDRD2HTR2ADRD1 | |
| SCHEMBL8596584 | 0.69 | ALDH1A1 (0.36) | — | |
| SCHEMBL9274148 | 0.67 | HTR1A (0.73) | HTR1AHTR1BDRD2HTR2A | |
| SCHEMBL9268702 | 0.67 | HTR1A (0.42) | HTR1AHTR1BDRD2HTR2ADRD1 | |
| SCHEMBL9270228 | 0.65 | HTR1A (0.63) | HTR1AHTR1BDRD2HTR2A | |
| SCHEMBL9268190 | 0.65 | HTR1A (0.56) | HTR1AHTR1BDRD2HTR2A | |
| SCHEMBL8557182 | 0.65 | HTR1A (0.74) | HTR1AHTR1BDRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564358-B1 | 3-aminochromane spiro derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-11-04 | — | — | EP | claimed |
| US-5420150-A | Antidepressants and treatment of anxiety | GUILLAUMET GERALD (FR) | 1995-05-30 | — | — | US | disclosed |
| US-5397783-A | Antidepressants, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1995-03-14 | — | — | US | disclosed |
| US-5376661-A | Psychological disorders | ADIR ET COMPAGNIE (FR) | 1994-12-27 | — | — | US | disclosed |