Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.45 |
| ▸ | DRD3 | P35462 | 6/20 | 0.45 |
| ▸ | DRD4 | P21917 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9268675 | 0.79 | OPRM1 (0.47) | OPRM1DRD3DRD4DRD2CYP2D6 | |
| SCHEMBL10346433 | 0.75 | OPRM1 (0.44) | OPRM1DRD3DRD4DRD2CYP2D6 | |
| SCHEMBL375036 | 0.70 | OPRM1 (0.53) | OPRM1DRD3DRD4DRD2MAPT | |
| SCHEMBL6073343 | 0.70 | OPRM1 (0.53) | OPRM1DRD3DRD4DRD2CYP2D6 | |
| SCHEMBL5642972 | 0.70 | KMT2A (0.57) | OPRM1DRD3DRD4DRD2CYP1A2 | |
| SCHEMBL10814384 | 0.70 | OPRM1 (0.53) | OPRM1DRD3DRD4DRD2CYP2D6 | |
| SCHEMBL6073374 | 0.68 | CYP1A2 (0.59) | OPRM1DRD3DRD4DRD2CYP2D6 | |
| SCHEMBL16158180 | 0.68 | OPRM1 (0.51) | OPRM1DRD3DRD4DRD2MAPT | |
| SCHEMBL6309263 | 0.68 | OPRM1 (0.65) | OPRM1DRD3DRD4DRD2CYP2D6 | |
| SCHEMBL11005256 | 0.68 | KMT2A (0.50) | OPRM1DRD3DRD4DRD2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436264-A | Adrenergic blocking agents for vasoconstriction and hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1995-07-25 | — | — | US | disclosed |