Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 4/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9275957 | 0.92 | HRH3 (0.44) | HRH3OPRK1 | |
| SCHEMBL9287812 | 0.91 | HTR7 (0.38) | HTR7MEN1KMT2AL3MBTL1MAOA | |
| SCHEMBL9279426 | 0.89 | HRH3 (0.39) | HRH3HTR7OPRK1MEN1KMT2A | |
| Azd-2927 SCHEMBL9105417 | 0.87 | MAOA (0.36) | HRH3OPRK1MEN1KMT2AL3MBTL1 | |
| Azd-2927 SCHEMBL9106608 | 0.87 | MAOA (0.36) | HRH3OPRK1MEN1KMT2AL3MBTL1 | |
| SCHEMBL10232050 | 0.86 | OPRK1 (0.38) | HRH3HTR7OPRK1MEN1KMT2A | |
| SCHEMBL9277120 | 0.86 | CHRM2 (0.39) | HRH3MEN1KMT2AL3MBTL1MAOA | |
| SCHEMBL9105601 | 0.84 | OPRK1 (0.35) | HRH3HTR7OPRK1MEN1KMT2A | |
| SCHEMBL9106299 | 0.84 | OPRK1 (0.35) | HRH3HTR7OPRK1MEN1KMT2A | |
| SCHEMBL9102296 | 0.83 | OPRK1 (0.36) | HRH3HTR7OPRK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012074469-A1 | NEW IKACH BLOCKERS | ASTRAZENECA AB (SE) | 2012-06-07 | — | — | WO | claimed |
| WO-2012074469-A1 | NEW IKACH BLOCKERS | ASTRAZENECA AB (SE) | 2012-06-07 | — | — | WO | disclosed |