SCHEMBL9273665

SCHEMBL9273665

CC(C)[Si](OC[C@H]1C[C@H](O)CC(=O)O1)(C(C)C)C(C)C

nearest known ligand 0.42

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 4/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9343987 1.00 HMGCR (0.42) HMGCR
SCHEMBL9273935 1.00 HMGCR (0.42) HMGCR
SCHEMBL13260909 0.84 HMGCR (0.41) HMGCR
SCHEMBL9264253 0.79 TOP2A (0.43) HMGCR
SCHEMBL10041024 0.77 HMGCR (0.43) HMGCR
SCHEMBL13768714 0.77 HMGCR (0.43) HMGCR
SCHEMBL3711795 0.74 RAB9A (0.34)
SCHEMBL455958 0.74 RAB9A (0.34)
SCHEMBL13701362 0.74 HMGCR (0.41) HMGCR
SCHEMBL20799714 0.74 HMGCR (0.41) HMGCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0604483-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES ZENECA LIMITED (GB) 1994-07-06 EP claimed
WO-1993006235-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES ZENECA LIMITED (GB) 1993-04-01 WO claimed
US-5443970-A SEPARATION OF ISOMERS IN A MIXTURE BY SELECTIVE REACTION ZENECA LIMITED (GB) 1995-08-22 US disclosed
EP-0604483-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES ZENECA LIMITED (GB) 1994-07-06 EP disclosed
WO-1993006235-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES ZENECA LIMITED (GB) 1993-04-01 WO disclosed