Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.71 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.71 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | BLM | P54132 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL29130842 | 1.00 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2LMNABLM | |
| Glycine SCHEMBL1023304 | 1.00 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2LMNABLM | |
| Glycine SCHEMBL28244367 | 0.97 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2LMNABLM | |
| Glycine SCHEMBL9637396 | 0.94 | OR51E2 (0.62) | GLRA1SLC6A9OR51E2LMNABLM | |
| Succinic Acid SCHEMBL14881109 | 0.91 | OR51E2 (0.59) | GLRA1SLC6A9OR51E2LMNABLM | |
| Glycine SCHEMBL25331208 | 0.88 | GLRA1 (0.56) | GLRA1SLC6A9OR51E2LMNABLM | |
| Glycine SCHEMBL25333156 | 0.88 | GLRA1 (0.56) | GLRA1SLC6A9OR51E2LMNABLM | |
| Glycine SCHEMBL11661976 | 0.87 | GLRA1 (0.62) | GLRA1SLC6A9OR51E2LMNABLM | |
| Methyl Phosphonate SCHEMBL758011 | 0.87 | GLRA1 (0.62) | GLRA1SLC6A9OR51E2LMNABLM | |
| Methyl Phosphonate SCHEMBL15419630 | 0.87 | GLRA1 (0.62) | GLRA1SLC6A9OR51E2LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290047-B1 | Dipyridoxyl phosphate nuclear magnetic resonance imagery contrast agents | NYCOMED SALUTAR INC (US) | 1995-02-01 | — | — | EP | disclosed |
| EP-0290041-B1 | Radioactive metal chelates of dipyridoxyl phosphate | NYCOMED SALUTAR INC (US) | 1993-12-08 | — | — | EP | disclosed |
| US-5223243-A | Dipyridoxyl phosphate chelating compound intermediates useful as NMRI contrast agents | SALUTAR, INC. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5130431-A | Chelate compound intermediates an NMR contrast agents | SALUTAR, INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5091169-A | Water soluble, stable chelates with paramagnetic metal ions | SALUTAR, INC. (US) | 1992-02-25 | — | — | US | disclosed |
| US-4992555-A | Certain dipyridylphosphate chelatable compounds capable of forming metal ion chelates | SALUTAR, INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4992554-A | Used as contrast agent in nuclear magnetic resonance imagery | SALUTAR, INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4933456-A | STABLE, SOLUBLE | SALUTAR, INC. (US) | 1990-06-12 | — | — | US | disclosed |
| US-4842845-A | Radioactive metal chelates for dipyridoxyl phosphate | SALUTAR, INC. (US) | 1989-06-27 | — | — | US | disclosed |
| EP-0290047-A2 | Dipyridoxyl phosphate nuclear magnetic resonance imagery contrast agents | NYCOMED SALUTAR, INC. (US) | 1988-11-09 | — | — | EP | disclosed |