Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.62 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.62 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | BLM | P54132 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL1023304 | 0.94 | GLRA1 (0.71) | OR51E2GLRA1SLC6A9LMNABLM | |
| Glycine SCHEMBL9274191 | 0.94 | GLRA1 (0.71) | OR51E2GLRA1SLC6A9LMNABLM | |
| Glycine SCHEMBL29130842 | 0.94 | GLRA1 (0.71) | OR51E2GLRA1SLC6A9LMNABLM | |
| Glycine SCHEMBL28244367 | 0.90 | GLRA1 (0.67) | OR51E2GLRA1SLC6A9LMNABLM | |
| Phosphoric Acid SCHEMBL28671057 | 0.87 | LMNA (0.43) | OR51E2GLRA1SLC6A9LMNABLM | |
| Phosphoric Acid SCHEMBL28671056 | 0.87 | LMNA (0.43) | OR51E2GLRA1SLC6A9LMNABLM | |
| Glycine SCHEMBL13739339 | 0.87 | — | — | |
| Glycine SCHEMBL29248317 | 0.87 | OR51E2 (0.83) | OR51E2GLRA1SLC6A9LMNABLM | |
| Succinic Acid SCHEMBL14881109 | 0.85 | OR51E2 (0.59) | OR51E2GLRA1SLC6A9LMNABLM | |
| Glycine SCHEMBL7030268 | 0.83 | OR51E2 (0.77) | OR51E2GLRA1SLC6A9LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164303-A | Biosynthesis | ZEAGEN, INC. (US) | 1992-11-17 | — | — | US | disclosed |
| US-5120655-A | From Candida famata culture | ZEAGEN, INC. (US) | 1992-06-09 | — | — | US | disclosed |