Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 4/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9077053 | 0.82 | HSD11B1 (0.45) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9447551 | 0.78 | KCNH2 (0.48) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9077025 | 0.78 | KCNH2 (0.50) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9677470 | 0.77 | LMNA (0.51) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9078685 | 0.77 | KCNH2 (0.51) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9077056 | 0.76 | KCNH2 (0.53) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9274868 | 0.75 | GRIN1 (0.52) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9089467 | 0.75 | KCNH2 (0.49) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9078574 | 0.73 | LMNA (0.38) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9090055 | 0.72 | CYP2C19 (0.47) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5478846-A | 1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-12-26 | — | — | US | disclosed |
| EP-0532629-A4 | — | — | 1994-03-09 | — | — | EP | disclosed |
| EP-0532629-A1 | 1-PYPERIDINYL ALKANOYLARYLSULFONAMIDE DERIVATIVES. | MERRELL DOW PHARMA (US) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991018603-A1 | 1-PYPERIDINYL ALKANOYLARYLSULFONAMIDE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-12-12 | — | — | WO | disclosed |