Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | PHGDH | O43175 | 2/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CLK1 | P49759 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12872285 | 1.00 | HTR3A (0.34) | HTR3AHRH4PHGDHTRPV3KDM4E | |
| SCHEMBL3046737 | 0.91 | HTR3A (0.36) | HTR3AHRH4TRPV3KDM4EALDH1A1 | |
| SCHEMBL3046733 | 0.91 | HTR3A (0.36) | HTR3AHRH4TRPV3KDM4EALDH1A1 | |
| SCHEMBL1188334 | 0.87 | HTR3A (0.32) | HTR3AHRH4 | |
| SCHEMBL8032394 | 0.87 | HTR3A (0.32) | HTR3AHRH4 | |
| SCHEMBL1186844 | 0.86 | TRPV3 (0.34) | HTR3AHRH4PHGDHTRPV3MEN1 | |
| SCHEMBL8038926 | 0.86 | TRPV3 (0.34) | HTR3AHRH4PHGDHTRPV3MEN1 | |
| SCHEMBL7715595 | 0.86 | CCNA2 (0.33) | TRPV3KDM4EALDH1A1 | |
| SCHEMBL194327 | 0.86 | CCNA2 (0.33) | TRPV3KDM4EALDH1A1 | |
| SCHEMBL8034806 | 0.86 | HRH4 (0.38) | HTR3AHRH4PHGDHTRPV3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214673-B1 | PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INT (DE) | 2012-05-30 | — | — | EP | disclosed |