Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7576170 | 0.88 | STAT3 (0.44) | TOP2ATOP2BKCNH2HRH3ADRB2 | |
| SCHEMBL5874340 | 0.85 | TOP2A (0.53) | TOP2ATOP2BKCNH2HRH3DPP4 | |
| SCHEMBL5422476 | 0.80 | ADRB2 (0.51) | TOP2ATOP2BADRB2DPP4CHRM2 | |
| SCHEMBL9088413 | 0.77 | TOP2A (0.48) | TOP2ATOP2BKCNH2HRH3DPP4 | |
| SCHEMBL14143512 | 0.76 | TOP2A (0.51) | TOP2ATOP2BKCNH2HRH3MEN1 | |
| SCHEMBL9688663 | 0.74 | TOP2A (0.55) | TOP2ATOP2BKCNH2MEN1KMT2A | |
| SCHEMBL9278706 | 0.74 | TOP2A (0.44) | TOP2ATOP2BKCNH2HRH3DPP4 | |
| SCHEMBL500472 | 0.74 | DPP4 (0.57) | TOP2ATOP2BDPP4CHRM2DRD1 | |
| SCHEMBL30181222 | 0.73 | ADRB2 (0.50) | TOP2ATOP2BKCNH2HRH3ADRB2 | |
| SCHEMBL5507636 | 0.73 | ADRB2 (0.50) | TOP2ATOP2BKCNH2HRH3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398967-A1 | ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1990-11-28 | — | — | EP | disclosed |
| WO-1989006649-A2 | ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-07-27 | — | — | WO | disclosed |