Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSH | P09668 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19248423 | 1.00 | TSHR (0.54) | TSHRCYP3A4ALDH1A1MAPK1TDP1 | |
| SCHEMBL20929244 | 1.00 | TSHR (0.54) | TSHRCYP3A4ALDH1A1MAPK1TDP1 | |
| SCHEMBL27549297 | 0.94 | TSHR (0.54) | TSHRCYP3A4ALDH1A1MAPK1TDP1 | |
| SCHEMBL20269906 | 0.90 | LMNA (0.51) | TSHRCYP3A4ALDH1A1MAPK1HPGD | |
| SCHEMBL27794811 | 0.86 | ESR1 (0.55) | TSHRCYP3A4ALDH1A1MAPK1TDP1 | |
| SCHEMBL16732085 | 0.85 | TSHR (0.55) | TSHRCYP3A4ALDH1A1MAPK1TDP1 | |
| SCHEMBL28557095 | 0.84 | TSHR (0.51) | TSHRCYP3A4ALDH1A1MAPK1TDP1 | |
| SCHEMBL2426331 | 0.84 | TSHR (0.54) | TSHRCYP3A4ALDH1A1MAPK1TDP1 | |
| SCHEMBL31257795 | 0.83 | CYP3A4 (0.55) | TSHRCYP3A4ALDH1A1MAPK1HPGD | |
| SCHEMBL1892061 | 0.83 | MMP8 (0.59) | TSHRCYP3A4ALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324174-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8207297-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-20120101050-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2012-04-26 | — | — | US | disclosed |
| US-20120101048-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2012-04-26 | — | — | US | disclosed |
| US-20120094930-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| US-8129346-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20080200398-A1 | Compounds For Enzyme Inhibition | PROTEOLIX, INC. (US) | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200398-A1 | Compounds For Enzyme Inhibition | ANPEP, DNPEP, CPN1 | TSHR 2729/4885CYP3A4 2068/4885ALDH1A1 2975/4885 |
| US-20120094930-A1 | COMPOUNDS FOR ENZYME INHIBITION | ANPEP, DNPEP, CPN1 | TSHR 2729/4885CYP3A4 2068/4885ALDH1A1 2975/4885 |
| US-20120101048-A1 | COMPOUNDS FOR ENZYME INHIBITION | ANPEP, DNPEP, CPN1 | TSHR 2729/4885CYP3A4 2068/4885ALDH1A1 2975/4885 |
| US-20120101050-A1 | COMPOUNDS FOR ENZYME INHIBITION | ANPEP, DNPEP, CPN1 | TSHR 2729/4885CYP3A4 2068/4885ALDH1A1 2975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.