Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | HRH2 | P25021 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | MGLL | Q99685 | 4/20 | 0.60 |
| ▸ | FAAH | O00519 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301729 | 0.90 | MGLL (0.64) | KMT2ASMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL7009534 | 0.89 | KMT2A (0.60) | KMT2ASMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL7392742 | 0.86 | KMT2A (0.72) | KMT2ASMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL7007723 | 0.86 | KMT2A (0.62) | KMT2ASMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL3996605 | 0.86 | MGLL (0.63) | ALDH1A1MGLLFAAHCYP1A2CYP2D6 | |
| SCHEMBL1734128 | 0.86 | MGLL (0.63) | ALDH1A1MGLLFAAHCYP1A2CYP2D6 | |
| SCHEMBL18971917 | 0.84 | CYP1A2 (0.57) | KMT2ASMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL9174650 | 0.84 | KMT2A (0.55) | KMT2ASMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL4380521 | 0.84 | MGLL (0.65) | KMT2ASMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL18424173 | 0.84 | CYP1A2 (0.73) | KMT2AALDH1A1MEN1MGLLFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9278982-B2 | Targeting human thymidylate kinase induces DNA repair toxicity in malignant tumor cells | NATIONAL YANG-MING UNIVERSITY (TW) | 2016-03-08 | — | — | US | disclosed |
| US-20130252953-A1 | Targeting Human Thymidylate Kinase Induces DNA Repair Toxicity in Malignant Tumor Cells | NATIONAL YANG-MING UNIVERSITY (TW) | 2013-09-26 | — | — | US | disclosed |
| US-20130252953-A1 | Targeting Human Thymidylate Kinase Induces DNA Repair Toxicity in Malignant Tumor Cells | NATIONAL YANG-MING UNIVERSITY (TW) | 2013-09-26 | — | — | US | disclosed |
| WO-2012072019-A1 | TARGETING HUMAN THYMIDYLATE KINASE INDUCES DNA REPAIR TOXICITY IN MALIGNANT TUMOR CELLS | CHANG ZEE-FEN (CN) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252953-A1 | Targeting Human Thymidylate Kinase Induces DNA Repair Toxicity in Malignant Tumor Cells | DTYMK, TYMP, DCK | KMT2A 1960/4885SMN1; SMN2 4078/4885ALDH1A1 1837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.