Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10440346 | 0.98 | GABRR1 (0.32) | GABRR1CHRNB2CHRNA7CHRNA4LMNA | |
| SCHEMBL4257138 | 0.96 | GABRR1 (0.31) | GABRR1CHRNB2CHRNA7CHRNA4LMNA | |
| SCHEMBL2034133 | 0.79 | CHRNB2 (0.33) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL4257139 | 0.78 | CHRNB2 (0.30) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL14893119 | 0.72 | — | — | |
| SCHEMBL9383434 | 0.68 | — | — | |
| SCHEMBL30877013 | 0.68 | KDM4E (0.33) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL963370 | 0.64 | GABRR1 (0.35) | GABRR1CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL19807406 | 0.61 | SLC6A3 (0.33) | GABRR1CHRNB2CHRNA7CHRNA4TSHR | |
| SCHEMBL25658 | 0.60 | CHRNA7 (0.71) | CHRNB2CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636133-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |