Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9277278 | 1.00 | CYP3A4 (0.43) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| Hydrochloric Acid SCHEMBL9277766 | 1.00 | CYP3A4 (0.43) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| Hydrochloric Acid SCHEMBL6562650 | 0.73 | CYP3A4 (0.41) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| Hydrochloric Acid SCHEMBL6563832 | 0.73 | CYP3A4 (0.41) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| Hydrochloric Acid SCHEMBL6564573 | 0.73 | CYP3A4 (0.41) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| Hydrochloric Acid SCHEMBL6566369 | 0.73 | CYP3A4 (0.41) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| Hydrochloric Acid SCHEMBL6564593 | 0.73 | CYP3A4 (0.41) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| Hydrochloric Acid SCHEMBL6562743 | 0.73 | CYP3A4 (0.41) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL11339049 | 0.73 | CYP3A4 (0.45) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| Hydrochloric Acid SCHEMBL9285166 | 0.71 | DNM1 (0.42) | TSHRALDH1A1DNM1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0349886-B1 | Liquid catalyst component, catalyst system containing said component and process for producing ethylene-alpha-olefin copolymer using said catalyst system | SUMITOMO CHEMICAL CO (JP) | 1995-09-20 | — | — | EP | disclosed |
| US-5134104-A | Coordination catalyst | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-07-28 | — | — | US | disclosed |
| US-5039766-A | Coordination polymerization catalyst | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1991-08-13 | — | — | US | disclosed |
| EP-0349886-A2 | Liquid catalyst component, catalyst system containing said component and process for producing ethylene-alpha-olefin copolymer using said catalyst system | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1990-01-10 | — | — | EP | disclosed |