Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL772622 | 0.96 | GPR84 (0.50) | GPR84FFAR1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL4383256 | 0.96 | GPR84 (0.50) | GPR84FFAR1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL5172958 | 0.96 | GPR84 (0.50) | GPR84FFAR1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8208352 | 0.78 | HTR1D (0.40) | SLC6A3SLC6A2SLC6A4HTR2AHTR6 | |
| SCHEMBL9287655 | 0.77 | HTR1D (0.42) | SLC6A3SLC6A2SLC6A4HTR2CHTR2A | |
| SCHEMBL8507358 | 0.77 | HTR1D (0.45) | SLC6A3SLC6A2SLC6A4HTR2AHTR6 | |
| SCHEMBL1697454 | 0.77 | SLC6A4 (0.43) | GPR84SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL8209129 | 0.77 | SLC6A4 (0.43) | GPR84SLC6A3SLC6A2SLC6A4HTR2C | |
| SCHEMBL8209090 | 0.77 | SLC6A4 (0.50) | GPR84SLC6A3SLC6A2SLC6A4HTR2A | |
| SCHEMBL774639 | 0.77 | SLC6A4 (0.43) | GPR84SLC6A3SLC6A2SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545644-A | SEROTONIN AGONISTS; HYPOTENSIVE AND ANXIOLYTIC AGENTS; ANALGESICS; ANTIDEPRESSANTS; EATING DISORDERS; DRUG ABUSE; HEADACHES; VASCULAR DISORDERS | PFIZER INC. (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0592438-A1 | INDOLE DERIVATIVES. | PFIZER (US) | 1994-04-20 | — | — | EP | disclosed |