Acrylonitrile

Acrylonitrile

SCHEMBL9282459

C=C(C=CC(=O)O)C(=O)OCC.C=CC#N

nearest known ligand 0.47

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.47
TSHR P16473 1/20 0.47
HCAR2 Q8TDS4 5/20 0.46
CYP2C9 P11712 1/20 0.38
KMT2A Q03164 5/20 0.34
MAPT P10636 4/20 0.34
MEN1 O00255 4/20 0.34
KDM4E B2RXH2 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
CYP2D6 P10635 1/20 0.33
NPC1 O15118 1/20 0.33
USP2 O75604 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
GAA P10253 1/20 0.33
THRB P10828 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL40331 0.88 HCAR2 (0.57) ALDH1A1TSHRHCAR2KMT2AMAPT
1,1-Dichloroethene SCHEMBL8342218 0.87 ALDH1A1 (0.37) ALDH1A1TSHRHCAR2CYP2C9KDM4E
Acrylic Acid SCHEMBL11216503 0.86 HCAR2 (0.52) ALDH1A1TSHRHCAR2KMT2AMAPT
Butadiene SCHEMBL11410298 0.86 HCAR2 (0.52) ALDH1A1TSHRHCAR2KMT2AMAPT
Acrylonitrile SCHEMBL315873 0.85 HCAR2 (0.51) ALDH1A1TSHRHCAR2MAPTKDM4E
1,1-Dichloroethene SCHEMBL6373416 0.83 HCAR2 (0.52) ALDH1A1TSHRHCAR2KMT2AMAPT
Acrylonitrile SCHEMBL3403014 0.83 HCAR2 (0.54) ALDH1A1TSHRHCAR2MAPTKDM4E
Acrylic Acid SCHEMBL10969441 0.83 ALDH1A1 (0.46) ALDH1A1TSHRHCAR2CYP2C9KMT2A
Methacrylic Acid SCHEMBL3440748 0.81 HCAR2 (0.50) ALDH1A1TSHRHCAR2KMT2AMAPT
Acrylonitrile SCHEMBL8018394 0.81 HCAR2 (0.41) ALDH1A1TSHRHCAR2KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-7305037-A None JP disclosed
JP-H07305037-A PRODUCT PRODUCED BY USING ADHESIVE COMPOSITION TREMCO INC 1995-11-21 JP disclosed