Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL748887 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1FPR2MAPK1POLB | |
| SCHEMBL205860 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1FPR2MAPK1POLB | |
| SCHEMBL13686130 | 0.81 | ALDH1A1 (0.36) | SMN1; SMN2ALDH1A1MEN1CYP2C9CYP2C19 | |
| SCHEMBL20614483 | 0.79 | LMNA (0.41) | SMN1; SMN2ALDH1A1MEN1CYP2C9CYP2C19 | |
| SCHEMBL893525 | 0.79 | HPGDS (0.36) | SMN1; SMN2ALDH1A1FPR2POLBMAPT | |
| SCHEMBL893526 | 0.79 | HPGDS (0.36) | SMN1; SMN2ALDH1A1FPR2POLBMAPT | |
| SCHEMBL13530960 | 0.79 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1FPR2MAPK1POLB | |
| SCHEMBL8350093 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1MEN1CYP2C9CYP2C19 | |
| SCHEMBL12463812 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1MEN1CYP2C9CYP2C19 | |
| SCHEMBL8130071 | 0.77 | DPP4 (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045463-B2 | Phenyl ethynyl derivatives as hepatitis C virus inhibitors | JANSSEN R&D IRELAND (IE) | 2015-06-02 | — | — | US | disclosed |
| US-20120136027-A1 | Phenyl Ethynyl Derivatives As Hepatitis C Virus Inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2012-05-31 | — | — | US | disclosed |
| WO-2011015657-A1 | PHENYL ETHYNYL DERIVATIVES AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS (IE) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136027-A1 | Phenyl Ethynyl Derivatives As Hepatitis C Virus Inhibitors | HAVCR2, ZC3HAV1, EIF2AK2 | SMN1; SMN2 4797/4885ALDH1A1 783/4885MEN1 4795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.