Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10922767 | 0.81 | MKNK1 (0.41) | RAB9ASMN1; SMN2CDK2DYRK1AMEN1 | |
| Hydrochloric Acid SCHEMBL10987600 | 0.79 | MKNK1 (0.41) | RAB9ASMN1; SMN2CDK2DYRK1AMEN1 | |
| SCHEMBL9182327 | 0.76 | IKBKB (0.47) | CHEK1NPC1RAB9ASMN1; SMN2IKBKB | |
| SCHEMBL9183883 | 0.75 | CNR1 (0.47) | CHEK1NPC1RAB9ASMN1; SMN2IKBKB | |
| SCHEMBL27759841 | 0.75 | CDK2 (0.45) | CHEK1NPC1RAB9ASMN1; SMN2DCLK1 | |
| SCHEMBL11070855 | 0.73 | RAB9A (0.50) | RAB9ASMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL10981820 | 0.72 | MAP2K4 (0.52) | CHEK1NPC1SMN1; SMN2PRKD3MAP4K4 | |
| SCHEMBL2614356 | 0.68 | IKBKB (0.50) | CHEK1NPC1RAB9ASMN1; SMN2IKBKB | |
| SCHEMBL14712058 | 0.67 | HSP90AA1 (0.56) | NPC1RAB9ASMN1; SMN2IKBKBCHUK | |
| SCHEMBL15741508 | 0.67 | NPC1 (0.43) | CHEK1NPC1RAB9ASMN1; SMN2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656897-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-14 | — | — | EP | disclosed |
| WO-1994005660-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1994-03-17 | — | — | WO | disclosed |