Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074145 | 0.83 | RAB9A (0.48) | RAB9AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL19715740 | 0.81 | RAB9A (0.48) | RAB9AMAPTALDH1A1MAPK1TP53 | |
| SCHEMBL14712058 | 0.79 | HSP90AA1 (0.56) | RAB9AMAPTALDH1A1MAPK1TP53 | |
| SCHEMBL7975685 | 0.77 | MAPT (0.41) | RAB9AMAPTALDH1A1TP53DUSP3 | |
| SCHEMBL7978314 | 0.75 | KDM4C (0.53) | RAB9AMAPTALDH1A1MAPK1POLB | |
| SCHEMBL29544871 | 0.73 | HPGDS (0.41) | RAB9AALDH1A1MAPK1MAP2K4KDM4C | |
| SCHEMBL10172559 | 0.73 | GAA (0.44) | RAB9AMAPTALDH1A1TP53ALPL | |
| SCHEMBL9284693 | 0.73 | CHEK1 (0.44) | RAB9AMAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL9183883 | 0.73 | CNR1 (0.47) | RAB9AMAPTALDH1A1MAPK1MAP2K4 | |
| SCHEMBL25171648 | 0.72 | DUSP3 (0.56) | RAB9AMAPTALDH1A1DUSP3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112623-A2 | 3-Aryl-5-pyrazole-carboxylic-acid derivatives, their preparation and pharmaceutical compositions | ELI LILLY AND COMPANY (US) | 1984-07-04 | — | — | EP | disclosed |