Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | IL6ST | P40189 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959983 | 0.84 | SRD5A1 (0.53) | OXER1SRD5A1SRD5A2MCL1 | |
| SCHEMBL8959660 | 0.83 | SRD5A1 (0.43) | OXER1PTGS2SRD5A1SRD5A2MCL1 | |
| SCHEMBL9289534 | 0.74 | ALOX12 (0.43) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL8959973 | 0.72 | SRD5A1 (0.59) | SRD5A1SRD5A2 | |
| SCHEMBL8959655 | 0.72 | SRD5A1 (0.49) | SRD5A1SRD5A2LMNA | |
| SCHEMBL8959858 | 0.72 | SRD5A1 (0.58) | SRD5A1SRD5A2 | |
| SCHEMBL8959830 | 0.72 | CNR1 (0.49) | SRD5A1SRD5A2LMNA | |
| SCHEMBL8960173 | 0.70 | PTGS1 (0.46) | PTGS2FAAHLMNA | |
| SCHEMBL9289530 | 0.70 | MAPT (0.56) | HPGDHDAC10HDAC6 | |
| SCHEMBL8959819 | 0.69 | MAPT (0.58) | HPGDMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0648208-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-19 | — | — | EP | disclosed |
| WO-1994022821-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |