Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.51 |
| ▸ | HAT1 | O14929 | 5/20 | 0.49 |
| ▸ | EP300 | Q09472 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9666677 | 0.88 | HPGD (0.54) | HPGDHSD17B10MAPTGAACYP2C19 | |
| SCHEMBL8802912 | 0.88 | HPGD (0.54) | HPGDHSD17B10MAPTGAACYP2C19 | |
| SCHEMBL9051473 | 0.86 | HPGD (0.52) | HPGDHSD17B10MAPTGAAMEN1 | |
| SCHEMBL9443458 | 0.86 | HPGD (0.52) | HPGDHSD17B10MAPTGAACYP2C19 | |
| SCHEMBL11714826 | 0.84 | GABRA1 (0.54) | HPGDHSD17B10MAPTCYP2C19MEN1 | |
| SCHEMBL10756907 | 0.82 | HPGD (0.46) | HPGDHSD17B10MAPTGAACYP2C19 | |
| SCHEMBL29728320 | 0.81 | HPGD (0.52) | HPGDHSD17B10MAPTMEN1KMT2A | |
| SCHEMBL27541984 | 0.80 | HPGD (0.47) | HPGDHSD17B10MAPTGAACYP2C19 | |
| SCHEMBL15557018 | 0.80 | HPGD (0.46) | HPGDHSD17B10MAPTGAACYP2C19 | |
| SCHEMBL10616315 | 0.80 | MEN1 (0.51) | HPGDHSD17B10MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680482-A1 | PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND. | PFIZER (US) | 1995-11-08 | — | — | EP | disclosed |