SCHEMBL9290200

SCHEMBL9290200

CNC(=O)c1cc(N)cc(C)c1NC(=O)C1CC(C(F)(F)F)=NN1c1ncccc1Cl

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 11/20 0.39
LMNA P02545 1/20 0.35
POLB P06746 1/20 0.35
TRPV1 Q8NER1 3/20 0.35
P2RX7 Q99572 1/20 0.33
RBP4 P02753 1/20 0.32
RIPK1 Q13546 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9290237 0.92 MALT1 (0.41) MALT1LMNAPOLBTRPV1RBP4
SCHEMBL13003161 0.92 MALT1 (0.37) MALT1TRPV1P2RX7RBP4
SCHEMBL9290246 0.91 MALT1 (0.39) MALT1LMNAPOLBTRPV1RBP4
SCHEMBL12575514 0.89 MALT1 (0.41) MALT1TRPV1P2RX7
SCHEMBL12437107 0.89 MALT1 (0.38) MALT1LMNAPOLBTRPV1
SCHEMBL12438369 0.88 MALT1 (0.40) MALT1TRPV1P2RX7
SCHEMBL9290202 0.87 MALT1 (0.37) MALT1LMNAPOLBTRPV1RBP4
SCHEMBL13338276 0.84 MALT1 (0.42) MALT1TRPV1RBP4
SCHEMBL9290245 0.83 MALT1 (0.40) MALT1TRPV1RBP4
SCHEMBL12294887 0.82 MALT1 (0.40) MALT1TRPV1RBP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012069008-A1 3-SUBSTITUTED SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES USEFUL AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2012-05-31 WO disclosed
WO-2010135914-A1 NEW SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2010-12-02 WO disclosed
WO-2010063670-A1 SPIROHETEROCYCLIC N-OXYAMIDES AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-06-10 WO disclosed
WO-2009024341-A2 CONDENSED ANTHRAN I LAMI DE DERIVATIVES AS INSECTISIDES SYNGENTA PARTICIPATIONS AG, (CH) 2009-02-26 WO disclosed
WO-2008101682-A2 IMINIPYRIDINE DERIVATIVES AND THEIR USES AS MICROBIOCIDES SYNGENTA PARTICIPATIONS AG (CH) 2008-08-28 WO disclosed
WO-2008064891-A1 N-CYANOALKYLANTHRANILAMIDES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2008-06-05 WO disclosed