SCHEMBL9290246

SCHEMBL9290246

CNC(=O)c1cc(Br)cc(C)c1NC(=O)C1CC(C(F)(F)F)=NN1c1ncccc1Cl

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 10/20 0.39
TRPV1 Q8NER1 3/20 0.35
LMNA P02545 1/20 0.33
POLB P06746 1/20 0.33
DHODH Q02127 2/20 0.33
RBP4 P02753 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12294887 0.92 MALT1 (0.40) MALT1TRPV1DHODHRBP4
SCHEMBL9290237 0.92 MALT1 (0.41) MALT1TRPV1LMNAPOLBRBP4
SCHEMBL12295362 0.92 MALT1 (0.37) MALT1TRPV1DHODHRBP4
SCHEMBL9290200 0.91 MALT1 (0.39) MALT1TRPV1LMNAPOLBRBP4
SCHEMBL9290241 0.89 MALT1 (0.41) MALT1TRPV1DHODH
SCHEMBL12438703 0.89 MALT1 (0.41) MALT1TRPV1DHODH
SCHEMBL12437107 0.89 MALT1 (0.38) MALT1TRPV1LMNAPOLB
SCHEMBL9290202 0.87 MALT1 (0.37) MALT1TRPV1LMNAPOLBRBP4
SCHEMBL13213026 0.86 TRPV1 (0.33) MALT1TRPV1LMNAPOLBDHODH
SCHEMBL13338276 0.84 MALT1 (0.42) MALT1TRPV1RBP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012092827-A1 CHEMICAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2012-07-12 WO disclosed
WO-2012069008-A1 3-SUBSTITUTED SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES USEFUL AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2012-05-31 WO disclosed
WO-2011095462-A1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2011-08-11 WO disclosed
EP-2332411-A1 Fungicidal compositions Syngenta Participations AG (CH) 2011-06-15 EP disclosed
WO-2011067240-A1 SPIRO FUSED 1 -AMINO - PIPERIDINE PYRROLIDINE DIONE DERIVATIVES WITH PESTICIDAL ACTIVITY SYNGENTA PARTICIPATIONS AG (CH) 2011-06-09 WO disclosed
WO-2011067135-A1 SPIRO FUSED 1 -AMINO - PIPERIDINE PYRROLIDINE DIONE DERIVATIVES WITH PESTICIDAL ACTIVITY SYNGENTA PARTICIPATIONS AG (CH) 2011-06-09 WO disclosed
EP-1778013-B1 FUNGICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2011-01-26 EP disclosed
WO-2010135914-A1 NEW SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2010-12-02 WO disclosed
EP-1871760-B1 CYANO ANTHRANILAMIDE INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-08-11 EP disclosed
EP-2213167-A1 Anthranilamide derivatives and their use for the control of insects and acari Syngenta Participations AG (CH) 2010-08-04 EP disclosed
WO-2010063670-A1 SPIROHETEROCYCLIC N-OXYAMIDES AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-06-10 WO disclosed
EP-1919903-B1 BICYCLIC BISAMIDE DERIVATIVES AND USE THEREOF AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-01-27 EP disclosed
WO-2009049851-A1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USEFUL AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2009-04-23 WO disclosed
WO-2009024341-A2 CONDENSED ANTHRAN I LAMI DE DERIVATIVES AS INSECTISIDES SYNGENTA PARTICIPATIONS AG, (CH) 2009-02-26 WO disclosed
WO-2009021717-A2 PESTICIDAL FORMULATION SYNGENTA PARTICIPATIONS AG (CH) 2009-02-19 WO disclosed
EP-1819695-B1 ANTHRANILAMIDE DERIVATIVES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2008-12-17 EP disclosed