SCHEMBL9290376

SCHEMBL9290376

N#CCCCN1C(=O)c2cccc3c(-c4ccccc4)ccc1c23

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.49
ALDH1A1 P00352 4/20 0.49
CYP1B1 Q16678 3/20 0.43
BRD4 O60885 6/20 0.42
SMN1; SMN2 Q16637 3/20 0.41
NPSR1 Q6W5P4 2/20 0.41
KDM4E B2RXH2 1/20 0.41
APAF1 O14727 1/20 0.41
GAA P10253 1/20 0.41
THRB P10828 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
NPC1 O15118 1/20 0.40
AVPR1A P37288 1/20 0.40
RAB9A P51151 1/20 0.40
HTR7 P34969 1/20 0.39
PKM P14618 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9290459 0.90 MAPT (0.43) MAPTALDH1A1CYP1B1BRD4SMN1; SMN2
SCHEMBL9290343 0.90 ALDH1A1 (0.43) MAPTALDH1A1CYP1B1BRD4SMN1; SMN2
SCHEMBL9290424 0.87 HTR1A (0.44) MAPTALDH1A1BRD4SMN1; SMN2NPSR1
SCHEMBL9290471 0.87 HTR1A (0.45) MAPTALDH1A1BRD4SMN1; SMN2NPSR1
SCHEMBL12561297 0.81 CYP1B1 (0.43) MAPTALDH1A1CYP1B1BRD4SMN1; SMN2
SCHEMBL9290365 0.81 KEAP1 (0.58) MAPTALDH1A1CYP1B1BRD4SMN1; SMN2
SCHEMBL9450607 0.80 ALDH1A1 (0.46) MAPTALDH1A1BRD4SMN1; SMN2NPSR1
SCHEMBL9290286 0.80 ALDH1A1 (0.46) MAPTALDH1A1BRD4SMN1; SMN2NPSR1
SCHEMBL9290372 0.78 ALDH1A1 (0.57) MAPTALDH1A1SMN1; SMN2L3MBTL1HTR7
SCHEMBL9290361 0.78 ALDH1A1 (0.46) MAPTALDH1A1CYP1B1BRD4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
EP-2458941-A1 OPTICAL FILTER Adeka Corporation (JP) 2012-05-30 EP disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152538-A1 OPTICAL FILTER C1R, CBR3, CBR1 MAPT 4299/4885ALDH1A1 776/4885CYP1B1 752/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.