SCHEMBL9291964

SCHEMBL9291964

OC(CCOc1c(Cl)ccc2ccccc12)c1ccc(Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.41
UTS2R Q9UKP6 1/20 0.39
HTR1A P08908 2/20 0.38
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
CYP2A6 P11509 1/20 0.36
GAA P10253 1/20 0.35
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
NPSR1 Q6W5P4 2/20 0.35
NPC1 O15118 1/20 0.35
ALDH1A1 P00352 1/20 0.35
XBP1 P17861 1/20 0.35
RAB9A P51151 1/20 0.35
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxalic Acid SCHEMBL9613749 0.82 SCN4A (0.39) KCNH2UTS2RSLC6A2SLC6A4GAA
SCHEMBL9291943 0.77 KDM4E (0.49) UTS2RHTR1ASLC6A2SLC6A4GAA
SCHEMBL16387726 0.71 MEN1 (0.58) HTR1ASLC6A4GAAMEN1KMT2A
SCHEMBL29376893 0.69 KCNA3 (0.55) SLC6A4MEN1KMT2AALDH1A1CYP1A2
SCHEMBL30600099 0.69 KCNA3 (0.55) SLC6A4MEN1KMT2AALDH1A1CYP1A2
SCHEMBL6678503 0.69 KCNA3 (0.55) SLC6A4MEN1KMT2AALDH1A1CYP1A2
SCHEMBL30600096 0.69 KCNA3 (0.55) SLC6A4MEN1KMT2AALDH1A1CYP1A2
SCHEMBL9291677 0.69 KCNA3 (0.55) SLC6A4MEN1KMT2AALDH1A1CYP1A2
SCHEMBL6675385 0.69 KCNA3 (0.55) SLC6A4MEN1KMT2AALDH1A1CYP1A2
SCHEMBL9613755 0.68 KCNH2 (0.39) KCNH2MEN1KMT2ANPSR1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5292962-A Intermediates to 1-phenyl-3-naphthalenyloxy-propanamines ELI LILLY AND COMPANY (US) 1994-03-08 US disclosed